View Full Version : FDA approved weight loss pill

Mike ODonnell
06-10-2007, 12:14 PM
All over the Sunday ads today...in every store...

Was only a matter of time....next up, Obesity as a disease that can only be treated by perscription meds....oh yeah...can't wait to hear all the problems people have in 2 years taking this....

Nikki Young
06-10-2007, 03:26 PM
Just out of curiosity, wouldn't all weight loss pills be FDA approved? Otherwise they wouldn't be allowed to stock on shelves.

Allen Yeh
06-11-2007, 05:04 AM
alli capsules only work on enzymes that break down fat, not on other enzymes. So carbohydrates and proteins are not affected. But, since fat grams have more than twice as many calories as carbs and protein, alli capsules work on the worst offenders — the calorie-dense fat grams. As you limit fat and calories through diet, use alli capsules, and get more physically active, your body will burn stored fat for energy. And that will help you lose weight. But remember, it will take hard work on your part. Individual results may vary.

The website hurts my brain.

Nikki, if it's a supplement and over the counter then it doesn't need to be regulated by the FDA i.e. Herbalife, Hydroxycut...etc

Mike ODonnell
06-11-2007, 06:45 AM
Just out of curiosity, wouldn't all weight loss pills be FDA approved? Otherwise they wouldn't be allowed to stock on shelves.

FDA doesn't control the supplement industry since it is the grey area between food and drugs....with all the money in that market you will see pharma companies pressuring the FDA to classify more things as diseases....and you can only legally treat a disease with a perscription drug....so if obesity is a disease, no supplement can claim to treat it.....it's all about the $

So wait...it's a capsule to inhibit the breakdown of dietary fat but they also want you to eat a low fat/cal diet and exercise....but their drug gets all the credit? Funny how that works....

David Wood
06-15-2007, 04:24 PM
Actually, folks, Alli is just the formerly prescription-only product Xenical (from Roche; Glaxo-SmithKline bought the rights to it as an OTC (over-the-counter) drug).

Alli will have half the dosage strength of Xenical (which will remain on the market as an Rx product). Studies suggest that this will deliver about 85% of the (rather meager) benefit that Xenical does.

MOD, agreed that the associated diet and exercise program that will be recommended will produce most of any results achieved. Taking any pill (a placebo) may be what some folks need to believe that it's worthwhile sticking with the D&E program, though, because, this time, with the magic pill's help, it's really going to work.

Taking orlistat (the generic name of the molecule in both drugs) does have one interesting side effect, however . . . since it inhibits the enzymes that digest fat, part of the fat you consume will pass through your digestive system (and out the back end) undigested. If the user consumes a large, fatty meal, the resulting discomfort and diarrhea are quite . . . "spectacular". As such, it provides a certain level of negative reinforcement on the original bad behavior.

Converting an "ethical" (Rx only) product to OTC is a process the FDA gets quite involved in . . . the petitioner (the drug company) has to convice the FDA that consumers can safely self-medicate. Not a rubber-stamp decision (Merck tried to take the statin drug Mevacor OTC a couple of years ago; it was rejected), and although the FDA regulates OTC meds much less closely than Rx meds, there is still some supervision and the possibility of reversal.

Going OTC is generally part of a revenue-maximizing strategy for most pharma companies, and is (typically) confounded by various end-of-patent-life issues (a company may be able to enjoy an extra 6 months of exclusivity as an OTC drug not available to it as an Rx product).

Incidentally, the history of weight-loss meds in America is one long tragicomedy for most involved (patients, and the drug companies). The drugs that actually work (amphetamines) have some somewhat disadvantageous side effects (addiction, anyone?). Phen-fen didn't work all that well, and produced heart problems. Xenical and Meridia both worked primarily through the placebo effect described above (i.e., they worked great, *if* you also did the diet and exercise program they recommended). Most studies showed that user would lose a handful of pounds (less than 5) more on the drugs than matched controls not using them, over the course of a year or more. Not much to write home about . . .

sanofi-aventis just lost (yesterday) their bid to bring rimonabant to the US market (it's sold in Europe under the name Acomplia) . . . suicide issues. Even that didn't work significantly better in studies than Xenical or Meridia.

I claim that rimonabant would have disappointed sanofi, even if they brought it to market: Amercan's don't *want* a product that will make it easier to stay on their diets (Xenical, Meridia, rimonabant). Instead, we want a product that lets us eat like a pig in slop, and still not get fat.

Greg Battaglia
06-20-2007, 10:51 PM
I have a sneaking suspicion that this drug will lead to fat-soluble vitamin deficiency. If it blocks the absorption of fat, it will block the absorption of D,E,A, and K. Consequently, it will probably increase the risk of cancer and heart disease due to deficiencies. Then to top it off, we just KNOW that any moron dumb enough to mess with a drug like this will no nothing about proper nutrition and likely either 1) eat a completely crap American diet, thinking the pill will balance it out, which will worsen deficiencies or 2) Reduce their fat intake, thinking it's the healthy route, again exasperating any deficiencies or finally 3) Do both and REALLY screw things up for themselves. Like Mike said, give it 2 years, if that.

Mike ODonnell
06-21-2007, 09:30 AM
If anything buy stock in Scott Industries....as TP sales will skyrocket from all the diarrhea...

http://www.youtube.com/watch?v=4n5rnMbwQb4&eurl=http%3A%2F%2Fwww%2Eproteinpower%2Ecom%2Fdrmik e%2F