View Full Version : Insulin Resistance

Daniel Miller
04-25-2007, 12:46 PM

I came across this paper today was was curious to see what peoples (Rob in particular) think about it.

here is a link: http://www.biomedcentral.com/1471-2148/7/61

Here is the abstract:
Evolutionary origins of Insulin Resistance: A behavioral switch hypothesis
Milind G Watve and Chittaranjan S Yajnik
BMC Evolutionary Biology 2007, 7:61 doi:10.1186/1471-2148-7-61
Published 17 April 2007
ABSTRACT: BACKGROUND: Insulin resistance, which can lead to a number of diseases including type 2 diabetes and coronary heart disease, is believed to have evolved as an adaptation to periodic starvation. The thrifty gene and thrifty phenotype hypotheses constitute the dominant paradigm for over four decades. With an increasing understanding of the diverse effects of impairment of the insulin signaling pathway, the existing hypotheses are proving inadequate. Presentation of the Hypothesis: We propose a hypothesis that insulin resistance is a socio-ecological adaptation that mediates two phenotypic transitions, (i) a transition in reproductive strategy from "r" (large number of offspring with little investment in each) to "K" (smaller number of offspring with more investment in each) and (ii) a transition from stronger to smarter or soldier to diplomat i.e. from relatively more muscle dependent to brain dependent lifestyle. A common switch could have evolved for the two transitions since the appropriate environmental conditions for the two transitions are highly overlapping and interacting. TESTING THE HYPOTHESIS: Gestational insulin resistance diverts more energy through the placenta, resulting in increased investment per offspring. On the other hand, insulin resistance is associated with reduced ovulation. The insulin signaling pathway is also related to longevity. Insulin resistance diverts more nutrients to the brain as compared to muscle. Also, hyperinsulinemia has direct positive effects on cognitive functions of the brain. The hypothesis gets support from known patterns in human clinical data and recent research on the molecular interactions in the insulin signaling pathway. Further we state many predictions of the hypothesis that can be tested experimentally or epidemiologically. IMPLICATIONS OF THE HYPOTHESIS: The hypothesis can bring about a significant change in the line of treatment as well as public health policies for the control of metabolic syndrome.

PMID: 17437648 [PubMed - as supplied by publisher]

Garrett Smith
04-25-2007, 02:12 PM
That made my brain hurt.

Seriously, are they trying to say that people with metabolic syndrome are smarter? I wouldn't agree based on what I've encountered...

I think it's part of the "we don't want anybody to feel bad about the choices they make" movement...

Babies that are being born that are too big to fit out of their mother's pelvis is surely not a "positive" adaptation!

Craig Cooper
04-25-2007, 05:51 PM
This runs right in line with the hypothesis that we will eventually have little need for our bodies as we become more and more technologically advanced. It's the new evolution! Let those who can do the least amount of exercise and eat the most processed crap and still live to reproduce survive!