I would change it up sometimes....
For example with a 5x5 set:
A) 5x5 85%RM - 2 min rest
B) 5x5 65%RM - 30 sec rest (something I took from Westside BB)
You get benefit from both in my book...and of course the best training is the one that keeps changing....so try both.....they will compliment each other in the long run