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Old 05-17-2008, 07:18 PM   #1
Neal Winkler
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Default Paradox People: Overweight, but good insulin sensitivity?

What do you think is going on with a person that appears to have good insulin sensitivity from blood tests (high HDL 55+, low triglycerides <60, low blood pressure, fasting glucose 85-90) and the fact that they maintain those numbers eating 200+ carbs per day with low activity, but at the same time are overweight. Body fat distribution is more so umbilical and iliac pattern. Female.

So, are they or are they not naturally insulin sensitive?

Blood markers lean yes given carb intake, body fat distribution and just the fact that they carry too much fat (33%+) lean no.

I'm thinking they are naturally insulin sensitive.
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Old 05-17-2008, 08:08 PM   #2
Mike ODonnell
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I am sure you will find some overweight people who can live to be 90....but I believe that is a rare and genetic gift....

Reminds of the guy in Mexico who was...Ummmm...like 700-900lbs? Geraldo went to save him....but when they tested him, perfect BP, HR and all other markers....minus the fact he looked like Jabba the hut and hadn't moved from his bed in 2 years.....but still...good genes....
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Old 05-24-2008, 01:42 PM   #3
Jared Buffie
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For one, they actually may be leptin resistant. Since leptin is realeased by fat cells, the receptrs on the hypothalams may be fried.

If they are in a "pre-diabetic" state, their bodies may be releasing more insulin to make up for the fact that the insulin receptors on the cells are starting to be fried, so for now their glucose levels are still normal. As those receptors continue to burn out, their glucose levels will rise because it can't enter the cells, and eventually they will be diagnosed as "diabetic", even though the process is underway right now. This is how it normally works with type II's, but since they don't measure insulin levels (only glucose), diabetes does not get diagnosed until later down the line. By then they'll be put on metformin, then glyboride, and eventually insulin.

What we do is put them on the "Healing Diet', where we cut out everything that is, or possibly could turn to, sugar. Basically Paleo without the high GI veggies, no fruit, and we say raw dairy is OK. Also, protein has to be 15-20 gr/meal, because that can break down into sugar under the right circumstances, which would lead to an insulin spike.

By completely avoiding insulin spikes for a prolonged period, their receptors WILL heal. We've had patients on insulin pumps get off them by following the Healing Diet. At the same time, the leptin receptors on the hypothalamus heal as well.
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Old 05-25-2008, 06:32 AM   #4
Garrett Smith
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Jared,
Do you have any info on this "Healing Diet" that you can send me?
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Old 05-26-2008, 05:48 PM   #5
Jared Buffie
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Garrett, here's the diets we use in our office:

Basic Diet - we recommend for everyone:

1. Change commercial meats to organic, grass fed free range
2. Change all fats to good fats - raw butter, olive oil, coconut milk/oil, etc..
3. Cut out sugar

On the basic diet, fruit and healthy grains are OK.

Healing Diet - for people with high triglycerides, cholesterol, blood sugar issues including diabetes, leptin resistance, neuritoxicity issues, and some people with a northern climate ancestry do well on it:

1. No sugar
2. No grains
3. No fruit (we can include grapefruit, berries and granny smith apples in moderation after week 3)
4. Switch to healthy fats
5. Moderate protein intake (15-25 gr per meal based on sex/activity level).

Here's a write-up from the guy who came up with it - he's a chiropractor friend of ours, and he does alot of neurotoxicity work as well. Check out his site
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Old 05-28-2008, 08:48 AM   #6
Craig Loizides
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Here are a couple more thoughts:

1. Different tissues become insulin resistant at different rates. Fat cells often become resistant after muscle and organs. It's possible that the fat cells still have good insulin sensitivity while other tissues do not. You can be both overweight and undernourished if the fat cells are stealing all the nutrients.

2. I think there is more to insulin resistance than just elevated insulin or high carbs. I'm leaning towards high insulin in the presence of high triglycerides/fat. Fructose might play a role, but it could just be in increased lipid production. I think some people can eat a high carb, high starch, moderate GI, low fat diet (food pyramid diet) resulting in high insulin levels and gain fat, but maintain insulin sensitivity. I think some studies have actually seen improved insulin sensitivity on a diet like this.

3. 200 g carbs isn't necessarily high. It works out to zone proportions on a 2000 calorie diet. But, I think most people will do better on less, especially if overweight with low activity.
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