“Hayflick limit...If you can figure out a way to give cells the characteristics of cancer...but without the downsides, you will have a very serious opportunity for life extension."
I have though about that often as of late, as my current project in the slammer revolves around a cell line that just keeps going and going and going (cue pink bunny).
We can do it, but it will be a team effort. You can have the profits from selling the method; I want first dibs on the publication rights.
Yall figure a way to slip in a mechanism for the controlled expression of the telomerase reverse transcriptase protein, maintain telomere lengths sufficient to avoid replicative senescence, and do this for every cell type in the body while maintaining a stable genotype.
Down here in So.Cal., I'll locate an ancient Amazonian virus, perform a few routine viral transformations, inactivate those tumor suppressor genes, then... this is the tricky part, keep them from becoming genetically unstable and convince them to retain the properties of the primary cells from which they were born.
Also, I’m thinking it might be handy to reintroduce the ascorbate synthase gene to the human genome. I can handle that part this afternoon.
Piece of cake.
Until next summer when we are done, my money is with a calorie/carb restricted diet, semi-regular Glassman-Wolf style workouts, some intermittent fasting, a lot of sleep, and less than zero stress.
I wrote this entire post without using the word Hormesis... but it was tough.