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Old 02-09-2009, 09:15 AM   #1
Greg Davis
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Default Lyle's Good Article on Coffee

Coffee, Diabetes and Weight Control - Research Review

good read for coffee drinkers..

note:
Quote:
and both the high antioxidant content of coffee along with the magnesium intake may improve insulin sensitivity in the long-term
As someone who supplements magnesium (and I think many others around here do) I thought I would check on how significant this actually is. Findings (nutritiondata.com & "natural calm"- a popular mag supplement):

1 tbsp natural calm: 205 mg
1 espresso shot: 24 mg
1 cup brewed coffee: 7.1 mg

Interesting that the espresso is much higher than coffee.. but still not very much compared to what actual supplementation would call for.

Just thought I'd share.
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Old 02-09-2009, 11:51 AM   #2
Garrett Smith
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It would seem possible that hormesis could explain some of the contradictory research findings.

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Hormesis (from Greek hórmēsis "rapid motion, eagerness," from ancient Greek hormáein "to set in motion, impel, urge on") is the term for generally-favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses.

As an example, challenging mice with small doses of gamma ray radiation shortly before irradiating them with very high levels of gamma rays actually decreases the likelihood of cancer[citation needed]. There is a similar effect when dioxin is given to rats[citation needed].

In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed “eustress”.

However, that hormesis is common or important has not been fully established. Indeed, the idea that low dose effects may be (sometimes strikingly) different is accepted, but that the low dose effect is positive is questionable. In one of the better studied areas of hormesis, radiation hormesis the United States National Research Council (part of the National Academy of Sciences),[1] the National Council on Radiation Protection and Measurements (a body commissioned by the United States Congress)[2] and the United Nations Scientific Committee on the Effects of Ionizing Radiation (UNSCEAR) all agree that radiation hormesis is not clearly shown, nor clearly the rule for radiation doses.

The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that a low dose challenge with a toxin may trigger certain repair mechanisms in the body, and these mechanisms, having been initiated, are efficient enough that they not only neutralize the toxin's effect, but even repair other defects not caused by the toxin.
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