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Old 06-19-2009, 10:54 PM   #1
Yael Grauer
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Default Phosphatidylserine

Just wondering if anybody's supplemented with phosphatidylserine and what your results were.
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Old 04-02-2010, 09:26 PM   #2
Steven Low
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I'm going to resurrect this thread.

---------------------------------

Great stuff, basically an anti-cortisol supplement. Very good if you're dealing with significant amounts of volume or stress on your body or somewhere thereabouts of overreaching/overtraining. Been helping me recover pretty well from my fatigue although I still need to hardcore rest more than I have been.

---------------------------------

That said....

I've been on the lookout for a cheap (quality) source of course...

I've hit up this one on iherb to good effect:
http://www.iherb.com/Life-Enhancemen...les/10248?at=0

It comes to approximately ~5 mg per cent or so.

So far best deal I've found is from puritan's pride albeit can't vouch for quality of it.... if you get the combo of buy 2 get 3 free you'll get 5 bottles for ~99 which is approximately ~9 mg/cents or almost 2x as cheap per.

Add in some random coupon on the web for like ~10% off or so and it goes to about 10 mg/cents which is exactly double.

http://www.puritan.com/lecithin-064/...-300-mg-017630

Only thing I'm concerned about is that it's in junky soybean oils and stuff, but then again 95% of the products I've looked at are as well. There's so little of it considering it's a soft gel that any fish oil intake should override the o-6 ratios, so I'm not too worried.

It's pretty much overpriced everywhere else including places like poliquin's site. You get ratios of < 2mg/cent in most cases.

I only believe in vitamin D and fish oil... but this stuff has certainly been making a case for how well it's helped improve quality of sleep and recovery capability.

(Haven't tried BCAAs or anything for what it's worth though...). Been getting my whey/casein mix from whole choco milk. Need to add my colostrum to it to see if it's better though.


Am likely going to write up an article on this.

Thoughts? Comments?
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Old 04-04-2010, 08:25 PM   #3
Steven Low
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Alrighty, well no one responded.

I'm gonna bite the bullet and order this stuff. I'll let you guys know how it goes comparitively.

If it's good I'll have enough of a supply to go up to 1g/day or so, and hopefully be able to recover to full capacity within a few weeks. As it is right now I don't have enough left of the Life Enhancement stuff to go hardcore like that.


Nevermind. Ordered. Good to go...
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Old 04-04-2010, 10:10 PM   #4
Garrett Smith
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I use it with folks when they have demonstrated high cortisol levels via the Adrenal Stress Index test (Diagnos-Techs).

A typical symptom of this is when someone can't fall asleep to begin with or wakes up middle of the night and simply cannot fall back asleep. However, I want to have the test to be sure that's what is going on.

Using it willy-nilly is hit or miss. I just had an athlete test with low cortisol levels at every time point. PS would not help him at all.
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Old 04-04-2010, 10:29 PM   #5
Steven Low
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Yep, this was a good read as well:

http://www.tmuscle.com/free_online_a...drenal_fatigue

I had pretty much the classic signs of screwed up cortisol output. Helped me sleep better significantly pretty instantly as well, and stay asleep longer. Has done me well.
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Old 04-05-2010, 03:41 AM   #6
Wayne Riddle
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Keep us updated Steven.
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Old 04-05-2010, 06:22 AM   #7
Tony Ferous
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You could try this powdered stuff, ive never ordered from them but they do seem pretty cheap, even for brand name stuff.
Anyone used their bulk powders?

http://www.bulknutrition.com/?products_id=2077

I bought a Poliquin podcast at the weekend(mass gain one), he mentions lowering cortisol serveral times, 2 tips being taking 1g of mg in split doses after 4pm and stretching before bed.

PS is meant to good for improving memory too of course.
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Old 04-05-2010, 07:22 AM   #8
Steven Low
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Quote:
Originally Posted by Tony Ferous View Post
You could try this powdered stuff, ive never ordered from them but they do seem pretty cheap, even for brand name stuff.
Anyone used their bulk powders?

http://www.bulknutrition.com/?products_id=2077

I bought a Poliquin podcast at the weekend(mass gain one), he mentions lowering cortisol serveral times, 2 tips being taking 1g of mg in split doses after 4pm and stretching before bed.

PS is meant to good for improving memory too of course.
They're about 6 mg/cent compared to the above 9-10 mg/cent. Meh.

50g total of PS (since you get 100g with 50% split) for the $89.

The above deal is 5 bottles * 60 pills * 300mg per pill = 90g total of PS for the $100 + possibly coupon discount. I think "EBATES" is the 10% off one.
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Old 04-06-2010, 12:26 PM   #9
Grissim Connery
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Quote:
Sports Med. 2006;36(8):657-69.
Effects of phosphatidylserine supplementation on exercising humans.

Kingsley M.

Department of Sports Science, University of Wales Swansea, Singleton Park, Swansea, UK. M.I.C.Kingsley@Swansea.ac.uk

Phosphatidylserine (PtdSer) is a ubiquitous phospholipid species that is normally located within the inner leaflet of the cell membrane. PtdSer has been implicated in a myriad of membrane-related functions. As a cofactor for a variety of enzymes, PtdSer is thought to be important in cell excitability and communication. PtdSer has also been shown to regulate a variety of neuroendocrine responses that include the release of acetylcholine, dopamine and noradrenaline. Additionally, PtdSer has been extensively demonstrated to influence tissue responses to inflammation. Finally, PtdSer has the potential to act as an effective antioxidant, especially in response to iron-mediated oxidation. The majority of the available research that has investigated the effects of PtdSer supplementation on humans has concentrated on memory and cognitive function; patients experiencing some degree of cognitive decline have traditionally been the main focus of investigation. Although investigators have administered PtdSer through intravenous and oral routes, oral supplementation has wider appeal. Indeed, PtdSer is commercially available as an oral supplement intended to improve cognitive function, with recommended doses usually ranging from 100 to 500 mg/day. The main sources that have been used to derive PtdSer for supplements are bovine-cortex (BC-PtdSer) and soy (S-PtdSer); however, due to the possibility of transferring infection through the consumption of prion contaminated brain, S-PtdSer is the preferred supplement for use in humans. Although the pharmacokinetics of PtdSer have not been fully elucidated, it is likely that oral supplementation leads to small but quantifiable increases in the PtdSer content within the cell membrane.A small number of peer-reviewed full articles exist that investigate the effects of PtdSer supplementation in the exercising human. Early research indicated that oral supplementation with BC-PtdSer 800 mg/day moderated exercise-induced changes to the hypothalamo-pituitary-adrenal axis in untrained participants. Subsequently, this finding was extended to suggest that S-PtdSer 800 mg/day reduced the cortisol response to overtraining during weight training while improving feeling of well-being and decreasing perceived muscle soreness. However, equivocal findings from our laboratory might suggest that the dose required to undertake this neuroendocrine action may vary between participants.Interestingly, recent findings demonstrating that short-term supplementation with S-PtdSer 750 mg/day improved exercise capacity during high-intensity cycling and tended to increase performance during intermittent running might suggest an innovative application for this supplement. With the findings from the existing body of literature in mind, this article focuses on the potential effects of PtdSer supplementation in humans during and following exercise.
If you want the full article but can't access it, just PM me.
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Old 04-06-2010, 05:42 PM   #10
Steven Low
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Yeah, I have a bunch of studies I've skimmed that look promising.
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