Phosphatidylserine - Page 4

Steven Low · 09-21-2010, 05:54 PM

Garrett,

Do you have any preference with GABA derivatives?

I have a regular bottle of GABA, but it didn't seem to really do anything for me. I've heard some derivatives are better than others at being absorbed though. Know of the specific ones?

Garrett Smith · 09-21-2010, 09:29 PM

Regular GABA cannot penetrate a patent blood-brain barrier, so if regular GABA works for someone, it implies "leaky brain".

phGABA (PharmaGABA) can penetrate the BBB, however, as Chad and I have discussed off-line, the body seems to adapt to it pretty quickly.

I use this product to help raise GABA levels. I like it quite a bit for myself, patients have liked the results too.

Yael Grauer · 09-21-2010, 10:44 PM

I've taken GABA and, although it did help with sleep, I found it mildly addictive.

Steven Low · 09-22-2010, 05:57 AM

Quote:

Originally Posted by Garrett Smith

Regular GABA cannot penetrate a patent blood-brain barrier, so if regular GABA works for someone, it implies "leaky brain".

phGABA (PharmaGABA) can penetrate the BBB, however, as Chad and I have discussed off-line, the body seems to adapt to it pretty quickly.

I use this product to help raise GABA levels. I like it quite a bit for myself, patients have liked the results too.

Yeah, that's what I thought in the GABA research reading I did. Regular GABA doesn't penetrate but I guess Ph does. I might try that.

Yael Grauer · 09-22-2010, 11:13 AM

Interesting, I read that liquid or sublingual does penetrate. What is leaky brain? LOL.

Garrett Smith · 09-22-2010, 11:37 AM

Quote:

Originally Posted by Yael Grauer

Interesting, I read that liquid or sublingual does penetrate. What is leaky brain? LOL.

http://www.articlealley.com/article_1043325_17.html

Basically a BBB that is allowing things to penetrate that shouldn't be...the neurological equivalent of leaky gut...although the two can go hand-in-hand.

Yael Grauer · 09-22-2010, 07:34 PM

Yeah, that's a Swiss cheesy argument.

Chad Cilli · 09-24-2010, 05:24 PM

Hey Dr. G, I know this thread moved on to GABA, but I've been trying a few different phosphatidylserine products to try to get the cheapest per dose, and I've noticed that powder products do nothing for me. But anything with the gelcaps seems to work. Especially anything with "Neuro PS" in it. I don't know if this is just an absorption thing or if it's something to do with digestion, but I thought it was something worth noting. With the capsules with powder in them, I can take literally grams of PS and feel nothing.

Garrett Smith · 12-20-2010, 05:15 AM

The original (and impressively positive) studies on PS were done on a PS+DHA complex obtained from cow brains. Since cow brains aren't exactly a desirable source of anything these days, and there have been mixed results with soy-derived PS by itself, I had an idea.

Last night, I put some EndoAmp Max (PS complex + alpha-GPC) in my mouth along with some high-DHA fish oil and emulsified D3 drops, and swished them around together until I felt they were really well mixed. I used the emulsified D3 in the hopes that the emulsification would help to mix everything together even better.

I really felt like the effects (making me very sleepy) hit me much harder and faster. Who knows, could be placebo.

Russell Crosswy · 01-28-2011, 01:08 PM

Is there a good book or source of info I can learn more about the GABA pathway?

Found this link which has a helpful illustration.