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Old 10-25-2007, 08:16 AM   #6
Garrett Smith
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Chris,
I will be covering this topic more in depth in a future PMenu article, meanwhile, here's some info to look at:

Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease.

Quote:
CONCLUSION: Concentrations of glycoalkaloids normally available while eating potatoes can adversely affect the mammalian intestine and can aggravate IBD.
Pathology in hamsters administered Solanum plant species that contain steroidal alkaloids.

Quote:
Syrian hamsters were orally administered ground plant material from either Solanum sarrachoides, S. melongena, S. eleagnifolium, or S. dulcamara. Six of eight hamsters administered S. eleagnifolium and eight of 10 hamsters administered S. dulcamara died following administration of plant material and had gastric glandular mucosal necrosis and small intestinal mucosal necrosis with little inflammation.
Mechanism of death in Syrian hamsters gavaged potato sprout material.

Quote:
To determine the cause of death in animals ingesting potato sprout material, 40 Syrian hamsters were divided into 4 equal groups and gavaged once on day 0 either water, 300 mg of potato sprout material, 400 mg of potato sprout material, or 500 mg of potato sprout material. Tissues were examined grossly and microscopically at 72 hr post-gavaging and brain acetylcholinesterase activity of each hamster was measured. The 300-mg dose group had increased mean acetylcholinesterase activity compared with control hamster mean activity, and the 400-mg and 500-mg dose groups had 90% and 84% of the mean acetylcholinesterase activity of the control hamster mean activity. There was severe gastric and proximal small intestinal mucosal necrosis in those hamsters which died prior to euthanasia.
Lesions of potato sprout and extracted potato sprout alkaloid toxicity in Syrian hamsters.

Quote:
Nine of 10 hamsters receiving dried potato sprout material and 3 of 5 hamsters receiving alkaloid extract had severe gastric and intestinal mucosal necrosis which was most severe in the glandular stomach, duodenum and proximal jejunum. All control hamsters gavaged with water and all hamsters gavaged with the potato sprout marc survived to the time of euthanasia and did not have gross or microscopic lesions.
Seriously, after seeing the documented evidence of GI lesions from multiple species of nightshades in both humans and animals, not eliminating them from the diet of someone with a GI disease is just plain wrong. I have to go, but take this seriously. I'm going to tell you that tomatoes do the same thing, potatoes are just MUCH worse for the GI tract.

Take them out of your diet completely. The evidence for induced pathology with peppers is even stronger, and eggplant contains the same alkaloids as potatoes do.

Sweet potatoes, yams, parsnips, and other root vegetables. It's an easy substitution.
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