I study both Escrima (Kali) and Wing Tsun (kung fu). Escrima is fairly direct in it's approach to self-defense. Also, it's not just a bladed system, it's a weapons systems. So, we're trained to see any object as a weapon.
I'm a smallish woman (5'2" and around 130lbs). I feel most confident when I have some sort of weapon in my hand.
Another system that I am intrigued with but have not had a chance to try is Krav Maga.