Originally Posted by Steven Low
Although it might be debatable whether you get a better stretch-shorten cycle from a muscle at the edge of its ROM instead of more flexibility than you need. Well, specifically stretched out muscle spindles may not provide as good of feedback if they are more flexible than they need to be; however, I don't think this makes THAT big of a difference. If we were to consider the foot placement in sprinting, high jump and long jump.. they don't operate at the edge of their ROM when performing these activities and also strongly utilize the stored energy from stretch-shorten cycle to perform at elite levels.
Do you have any data on that Greg?
You should get a better stretch reflex in the mid ROM because you're going to get the best actin-myosin coupling. More flexibility = longer resting length via sarcomere addition = mid ROM is farther out. So really you just need to decide 1) what the necessary ROM is and 2) where you need maximal tension in the pertinent movements. You may not be able to get the two to coincide well, so you want to minimize disruptions to each by the other.