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Old 11-05-2009, 11:12 AM   #6
Mike ODonnell
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Also interesting to note that "protein pulsing" is also seen to be more effective than just eating all day long (and intakes are pretty high below).

Protein pulse feeding improves protein retention in elderly women1,2,3
Marie-Agnès Arnal, Laurent Mosoni, Yves Boirie, Marie-Louise Houlier, Liliane Morin, Elisabeth Verdier, Patrick Ritz, Jean-Michel Antoine, Jacques Prugnaud, Bernard Beaufrère and Philippe Patureau Mirand

Background: Adequate protein nutrition could be used to limit gradual body protein loss and improve protein anabolism in the elderly.

Objective: We tested the hypothesis that an uneven protein feeding pattern was more efficient in improving protein anabolism than was an even pattern.

Design: After a controlled period, 15 elderly women (mean age: 68 y) were fed for 14 d either a pulse diet (n = 7), providing 80% of the daily protein intake at 1200, or a spread diet (n = 8), in which the same daily protein intake was spread over 4 meals. Both diets provided 1.7 g protein•kg fat-free mass (FFM)-1•d-1. Protein accretion and daily protein turnover were determined by using the nitrogen balance method and the end product method (ammonia and urea) after an oral dose of [15N]glycine.

Results: Nitrogen balance was more positive with the pulse than with the spread diet (54 ± 7 compared with 27 ± 6 mg N•kg FFM-1•d-1; P < 0.05). Protein turnover rates were also higher with the pulse than with the spread diet (5.58 ± 0.22 compared with 4.98 ± 0.17 g protein•kg FFM-1•d-1; P < 0.05), mainly because of higher protein synthesis in the pulse group (4.48 ± 0.19 g protein•kg FFM-1•d-1) than in the spread group (3.75 ± 0.19 g protein•kg FFM-1•d-1) (P < 0.05).

Conclusion: A protein pulse-feeding pattern was more efficient than was a protein spread-feeding pattern in improving, after 14 d, whole-body protein retention in elderly women.
and actually T-nation has an article about that as well (including reference to the study above):

Hence why many have success with some larger protein meals and there is much more going on with the body as a whole....rather than always micro-focusing on meal to meal response, whole body up-regulation and increased utilization is important.
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