I do think the negative effect on the adrenals of low-carb, IF, and/or Zone over time play a huge role. One of the first things I do with adrenal fatigue folks is get them to eat more carbs in general and ditch the IF. This can have them feeling significantly better within a week.
Brandon, you're being a bit glib by including "refeeding syndrome" in this context...unless you know of an IFer or low-carber dying from a refeed day.
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