The first breakdown from training is neurological, your brain trying to tell you that you are doing too much.
The second breakdown is physical, which has all sorts of manifestations, generally depending on where someone has "chinks in their armor".
Read this: http://www.t-nation.com/free_online_...drenal_fatigue
That generally covers a lot of the approach I use.
I've personally never used CLT, but I'm sure Poliquin has used buckets full.