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Old 11-18-2010, 07:57 AM   #1
Grissim Connery
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Default Possible mechanism for trans fats and atherosclerosis

J Nutr Biochem. 2010 Oct 30. [Epub ahead of print]

A mechanism by which dietary trans fats cause atherosclerosis.
Chen CL, Tetri LH, Neuschwander-Tetri BA, Huang SS, Huang JS.

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, St. Louis, MO 63104, USA.

Dietary trans fats (TFs) have been causally linked to atherosclerosis, but the mechanism by which they cause the disease remains elusive. Suppressed transforming growth factor (TGF)-β responsiveness in aortic endothelium has been shown to play an important role in the pathogenesis of atherosclerosis in animals with hypercholesterolemia. We investigated the effects of a high TF diet on TGF-β responsiveness in aortic endothelium and integration of cholesterol in tissues. Here, we show that normal mice fed a high TF diet for 24 weeks exhibit atherosclerotic lesions and suppressed TGF-β responsiveness in aortic endothelium. The suppressed TGF-β responsiveness is evidenced by markedly reduced expression of TGF-β type I and II receptors and profoundly decreased levels of phosphorylated Smad2, an important TGF-β response indicator, in aortic endothelium. These mice exhibit greatly increased integration of cholesterol into tissue plasma membranes. These results suggest that dietary TFs cause atherosclerosis, at least in part, by suppressing TGF-β responsiveness. This effect is presumably mediated by the increased deposition of cholesterol into cellular plasma membranes in vascular tissue, as in hypercholesterolemia.

Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 21036587 [PubMed - as supplied by publisher]
not sure if there are criticisms of the study yet, but it's fun.
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