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Old 01-15-2009, 10:10 PM   #1
Gaspard Winckler
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Default De Vany and insulin 'sunburn'?

Thanks for all the free advice I have obtained from this forum!

Art De Vany says:

"Insulin spikes, particularly large ones, kill more receptors or damage or downturn or down-regulate receptor sensitivity more than does a lower but chronic amount. It's like life is built up with lots of shocks, and the big shocks will be the huge print on your genetic composition and your gene expression and on your hormone profiles and the sensitivities to those hormones.

So, for example, a transitory shock of insulin after a Thanksgiving meal, followed by a good dessert and maybe preceded by wine and followed by a liquor, that mark's left on your metabolism for a very long time."

Is this supported in any way scientifically? If true, it would seem to speak against a 5 day, 2 day split of paleo IF and more relaxed weekend eating. Intuitively the idea of receptor 'killing' doesn't ring true for me at all, though. Recovery from too much 'social eating/ drinking' seems fairly fast on a 5/2 cycle.
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Old 01-16-2009, 08:07 AM   #2
Mike ODonnell
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He's downplaying the role that the body has in regenerating and healing itself with IF. Not sure there is any real research to back it up nor deny his claims though (or at least I have not come across any). You could go back to the old Mattson 1meal vs 3 meal study with IF and how 1 meal a day people had higher fasting am insulin...but there are flaws to that as they had complete "carb bomb" meals once a day and then only took fasting insulin in the AM....where later in the day it probably would have been lower. Not a perfect study but does shed some light on at least trying to eat moderate and more often than 1x a day.

I don't eat like it's Thanksgiving on a daily basis or weekly basis...so not sure that's a great comparison. One should be able to tell what is or is not working....as if you increase insulin resistance then you will see more "fat" gain vs loss...if you are leaning out then I guess it's not as damaging as he states. Only other way would be to monitor fasting insulin.

Since exercise also increases insulin sensitivity, the results may differ when talking about sedentary individuals vs active ones. Too many variables to consider.

Comes down to the same saying....IFOC (IF on Crap) isn't a good idea.
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Old 01-16-2009, 10:49 AM   #3
Gaspard Winckler
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Thanks Mike, it seemed a bit too much of an 'alcohol kills brain cells' type statement, and the counter evidence is all the people doing a variety of IF/ Paleo/ Zone with cheat days and no ill effects.
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Old 01-16-2009, 12:12 PM   #4
Jeremy Shepard
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His new hard-on against good eating is theoretical epigenetic transmission of the damage to your offspring, which he pulled right out of his ass. I'm fairly convinced a large portion of his posts come from there, though.

Seriously, if my kids can't handle my cheesecake addiction, screw 'em. They'll just have to lift a little harder.
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Old 01-16-2009, 06:34 PM   #5
Patrick Yeung
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I remember an article on the NY Times with a title saying something like... "One hamburger can ruin a month's worth of dieting"

But, their whole thing was that, once you ate it, or other junk food, the resulting insulin spike would cause you to be hungry/crave again. And, then the cycle starts. A slippery slope if you ask me.

It sounds similar to what Art is saying, just not so much savvy jargon. I think both dont take into mind that some of us are disciplined and can work through pain and a little hunger...

Besides, if either were true, then how could anyone diet? I mean, didnt we all used to eat all that junk? I know I used to eat it every meal, am I lost forever?
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Old 01-17-2009, 05:57 AM   #6
Mike ODonnell
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If one bad night of eating and drinking with a big insulin spike ruins your cells for a lifetime.....I should be about 500lbs right now after all the damage from college.
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Old 03-09-2009, 12:00 PM   #7
Patrick Yeung
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I know this is kind of old, but thought maybe this would interest people.

Lower I.Q. Scores Among Children of Older Fathers
http://www.nytimes.com/2009/03/10/he...tml?ref=health

Talked about how children with older fathers scored lower on all cognitive tests, and showed much higher risk of schizophrenia and autism than those of younger fathers.

Also showed children of older mothers had better scores.

Whats crazy though, was that it was a linear progression in the case of dads. I wonder why that is, and if it has anything to do with this (genetic degredation), or more the nurture side.
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Old 10-13-2009, 12:41 PM   #8
Craig Van De Walker
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I vote both nature and nurture. Nurture from the older mother vs a potentially less well equipped younger mother.

Nature in that the women who have children with older men may not on the average be as intelligent as the women who have children with same age men. I say this because a 60 year old women is not normally able to have children so a 60 year old man must be having children with a significantly younger woman.

Without adjusting for the mother and father's IQ I don't think this is a very valid observation.

I know this is anecdotal but the only women I know who had children late in life were well educated and appeared intelligent.
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