I'm no Glenn Pendlay, obviously, here's my $0.02 anyway.
I try to do different variations when I can and when I think the variations have benefits. If I'm doing a variation on a "major" lift, I try to make sure it is different enough than the most important version to not confuse the motor patterns.
For example, doing "B" squats as a portion of my back/front squat sets. Different enough not to confuse motor patterns for sure. I think "B" squats are highly underrated and underutilized, along with having athletic benefits from the staggered stance.
I would use my clean grip (including the hook) for my DLs, along with a similar stance, as my OLs will always have priority over my PLs.
I would use the same grip on all of my presses. That said, I get all sorts of extra "different" work pressing with the gymnastics stuff (no bar most times, obviously).
I don't have a specific goal though, other than enjoying my training, feeling athletically "capable" and being competitive in Master's OL in a couple of years. I figure if I stay healthy (by doing variations to both stay strong in many different ways while minimizing repetitive mechanical wear patterns on the joints) than there won't be much issue.
For those who wish to be specific and as competitive as possible, I don't believe my approach to be optimal in any way.