Go Back   Catalyst Athletics Forums > Nutrition > General Nutrition

Reply
 
Thread Tools Display Modes
Old 04-15-2011, 05:15 AM   #1
Darryl Shaw
Senior Member
 
Join Date: Apr 2008
Posts: 706
Default Intermittent Fasting Does Not Affect Whole-Body Glucose, Lipid or Protein Metabolism.

Quote:
Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism.

Abstract


Background: Intermittent fasting (IF) was shown to increase whole-body insulin sensitivity, but it is uncertain whether IF selectively influences intermediary metabolism. Such selectivity might be advantageous when adapting to periods of food abundance and food shortage.

Objective: The objective was to assess effects of IF on intermediary metabolism and energy expenditure.

Design: Glucose, glycerol, and valine fluxes were measured after 2 wk of IF and a standard diet (SD) in 8 lean healthy volunteers in a crossover design, in the basal state and during a 2-step hyperinsulinemic euglycemic clamp, with assessment of energy expenditure and phosphorylation of muscle protein kinase B (AKT), glycogen synthase kinase (GSK), and mammalian target of rapamycine (mTOR). We hypothesized that IF selectively increases peripheral glucose uptake and lowers proteolysis, thereby protecting protein stores.

Results: No differences in body weight were observed between the IF and SD groups. Peripheral glucose uptake and hepatic insulin sensitivity during the clamp did not significantly differ between the IF and SD groups. Likewise, lipolysis and proteolysis were not different between the IF and SD groups. IF decreased resting energy expenditure. IF had no effect on the phosphorylation of AKT but significantly increased the phosphorylation of glycogen synthase kinase. Phosphorylation of mTOR was significantly lower after IF than after the SD.

Conclusions: IF does not affect whole-body glucose, lipid, or protein metabolism in healthy lean men despite changes in muscle phosphorylation of GSK and mTOR. The decrease in resting energy expenditure after IF indicates the possibility of an increase in weight during IF when caloric intake is not adjusted.
http://www.ajcn.org/content/90/5/1244.long
Darryl Shaw is offline   Reply With Quote
Old 04-15-2011, 09:45 AM   #2
Emily Mattes
Senior Member
 
Join Date: Jul 2008
Posts: 727
Default

I thought most IFers assumed this? The advantages of IF are meal timing and the increase in insulin sensitivity. Insulin sensitivity improvements can, over the long term, improve rates of fat deposition.
Emily Mattes is offline   Reply With Quote
Old 04-15-2011, 11:00 PM   #3
Kevin Perry
Senior Member
 
Join Date: Jul 2007
Posts: 1,672
Default

2 weeks doesn't seem long enough for anything conclusive
Kevin Perry is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump




All times are GMT -7. The time now is 09:26 PM.

Powered by vBulletin® Version 3.8.9 Beta 3
Copyright ©2000 - 2014, vBulletin Solutions, Inc.