Home   |   Contact   |   Help

Get Our Newsletter
Sign up for our free newsletter to get training tips and stay up to date on Catalyst Athletics, and get a FREE issue of the Performance Menu journal.

Go Back   Catalyst Athletics Forums > Nutrition > General Nutrition

Reply
 
Thread Tools Display Modes
Old 09-26-2008, 02:39 PM   #1
Garrett Smith
Senior Member
 
Garrett Smith's Avatar
 
Join Date: Feb 2007
Location: Tucson, AZ
Posts: 4,368
Default New data on sucralose!!! Um, it's bad, mmmkay?

For all those of you who have friends/family/clients who are unwilling to believe that there is any evidence out there of problems with the "FDA approved" Splenda/sucralose artificial sweetener, here we go with some hard data:

Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats.

Quote:
Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P-gp) and the cytochrome P-450 (CYP) metabolism system by Western blot. The remaining animals were allowed to recover for an additional 12-wk, and further assessments of fecal microflora, fecal pH, and expression of P-gp and CYP were determined. At the end of the 12-wk treatment period, the numbers of total anaerobes, bifidobacteria, lactobacilli, Bacteroides, clostridia, and total aerobic bacteria were significantly decreased; however, there was no significant treatment effect on enterobacteria. Splenda also increased fecal pH and enhanced the expression of P-gp by 2.43-fold, CYP3A4 by 2.51-fold, and CYP2D1 by 3.49-fold. Following the 12-wk recovery period, only the total anaerobes and bifidobacteria remained significantly depressed, whereas pH values, P-gp, and CYP3A4 and CYP2D1 remained elevated. These changes occurred at Splenda dosages that contained sucralose at 1.1-11 mg/kg (the US FDA Acceptable Daily Intake for sucralose is 5 mg/kg). Evidence indicates that a 12-wk administration of Splenda exerted numerous adverse effects, including (1) reduction in beneficial fecal microflora, (2) increased fecal pH, and (3) enhanced expression levels of P-gp, CYP3A4, and CYP2D1, which are known to limit the bioavailability of orally administered drugs.
__________________
Garrett Smith NMD CSCS BS, aka "Dr. G"
RepairRecoverRestore.com - Blood, Saliva, and Stool Testing
My radio show - The Path to Strength and Health
Garrett Smith is offline   Reply With Quote
Old 09-26-2008, 02:59 PM   #2
Dave Van Skike
Senior Member
 
Join Date: Dec 2006
Location: PNW
Posts: 1,738
Default

I always though that stuff was gross tasting, apparently even gut bacteria don't like it...naaaaaasty..
__________________
Practical Strength
Dave Van Skike is offline   Reply With Quote
Old 09-26-2008, 05:11 PM   #3
Mike ODonnell
Senior Member
 
Mike ODonnell's Avatar
 
Join Date: Nov 2006
Posts: 3,596
Default

You mean artificial chemicals added to processed foods and approved by an understaffed government agency for human consumption may be bad afterall? Whodathunkit?
__________________
Fitness Spotlight
The IF Life
Mike ODonnell is offline   Reply With Quote
Old 09-26-2008, 05:28 PM   #4
Garrett Smith
Senior Member
 
Garrett Smith's Avatar
 
Join Date: Feb 2007
Location: Tucson, AZ
Posts: 4,368
Default

MOD,
It's not simply an understaffed agency, it's also overbribed and corrupt to its very core. Let's not forget the things it is good at...
__________________
Garrett Smith NMD CSCS BS, aka "Dr. G"
RepairRecoverRestore.com - Blood, Saliva, and Stool Testing
My radio show - The Path to Strength and Health
Garrett Smith is offline   Reply With Quote
Old 09-26-2008, 07:22 PM   #5
George Mounce
Senior Member
 
Join Date: Mar 2008
Location: Mississippi
Posts: 945
Default

As always great stuff you find to show that real food is and always will be just that, real food. Anything contrary is crap!
George Mounce is offline   Reply With Quote
Old 09-27-2008, 05:01 PM   #6
sarena kopciel
Senior Member
 
Join Date: Dec 2006
Posts: 674
Default

Well more on the food and political connection in this book I read today.

I wasn't shocked to say the least, especially as I attended an all day Autism Symposium just 2 days ago and all the "professionals" talked about were finding the gene that causes autism and the new "breakthoughs" in various pharmaceuticals. They even mentioned how diet and Omega 3 use had been debunked. Yet there is currently 1:150 kids born with autism. When are we as a nation gonna learn?

As if I didnt know better, the food served was textbook HELL. Danish and bagels for breakfast. Wraps, soda and pitchers of tap water for lunch!

Yet the doctors and PhDs all talked about the similarities between kids with autism but harped on the fact that there were far more dissimilarities between the same children. Now how can they say that diet or supps dont help? And how many shots are we indoctrinated in giving our youth in their first 2 years.

End of rant.....
sarena kopciel is offline   Reply With Quote
Reply


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -7. The time now is 03:51 AM.

Powered by vBulletin Version 3.6.2
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Subscribe to our Newsletter


Receive emails with training tips, news updates, events info, sale notifications and more.
ASK GREG

Submit your question to be answered by Greg Everett in the Performance Menu or on the website

Submit Your Question
WEIGHTLIFTING TEAM

Catalyst Athletics is a USA Weightlifting team of competitive Olympic-style weightlifters with multiple national team medals.

Read More
Olympic Weightlifting Book
Catalyst Athletics
Contact Us
About
Help
Newsletter
Products & Services
Gym
Store
Seminars
Weightlifting Team
Performance Menu
Magazine Home
Subscriber Login
Issues
Articles
Workouts
About the Program
Workout Archives
Exercise Demos
Text Only
Instructional Content
Exercise Demos
Video Gallery
Free Articles
Free Recipes
Resources
Recommended Books & DVDs
Olympic Weightlifting Guide
Discussion Forum
Weight Conversion Calculator